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Furthermore, when combined with anti-PD1 or anti-CTLA4 antibodies, CB-839 promotes the infiltration of effector T cells into tumors and upregulates IFN-associated gene expression, thereby enhancing the antitumor activity of these checkpoint inhibitors [199]

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Epithelial and intestinal models: KPV has been studied in mouse models of colitis and in research involving epithelial inflammatory responses